Salicylic acid‐enhanced biosynthesis of pharmacologically important lignans and neo lignans in cell suspension culture of Linum ussitatsimum L

Improvement of lignans production in hairy root culture of Linum mucronatum using abiotic and biotic elicitors .

Elicitors could be used as the enhancer of plant secondary-metabolite synthesis and could play an important role in biosynthetic pathways of important medicinal compounds. The present study investigated the effect of abiotic elicitor (fungal extract of Fusarium graminearum) and two abiotic elicitors (methyl jasmonate and salicylic acid) at different concentrations in 18- and 30-day-old cultures...

Accumulation of lignans in suspension cultures of Linum mucronatum ssp. armenum (Bordz.) Davis.

For the first time callus and suspension cultures of Linum mucronatum ssp. annenum were initiated, grown in darkness at 25 degrees C and analyzed for lignans. 6-Methoxypodophyllotoxin was the main lignan besides smaller amounts of podophyllotoxin isolated and identified by chromatographic methods as well as by 1H NMR.

Biosynthesis of tetrahydrofuran lignans in Virola surinamensis

The Effect of Chitosan and Chitin Oligomers on Gene Expression and Lignans Production in Linum album Cell Cultures

Background: Linum album, a herbaceous and medicinal plant, has been shown to accumulate anti-tumor podophyllotoxin (PTOX) and related lignans. Objective: In this study, we have verified the time-course of cell growth, lignan production in cells treated with chitosan and chitin oligomers. To study mechanism of chitosan and chitin oligomers action, expression of phenylalanine ammonio-lyase (PAL)...

Quantification of Aryltetralin Lignans in Linum album Organs and In Vitro Cultures

      A procedure was developed for rapid in vitro germination of Linum album seeds by scarification and exposing to gibberellic acid (GA3) and kinetin (Kn).  Concentrations of podophyllotoxin (PTOX) and related aryltetralin lignans α-peltatin, β-peltatin, 5’-demethoxy-6-methoxypodophyllotoxin and 6-methoxypodophyllotoxin (MPTOX) in L. album fresh plant org...